Vs System 2PCG: Legacy is a set of two hundred cards that expands on all of the Marvel Universe teams released to date for the Vs System 2PCG line: The Marvel Battles, The Defenders, and A-Force. Each team gains a new main character and a few supporting characters, including fan favorites such as Captain Britain, Psylocke, Mister Sinister, Taskmaster, Squirrel Girl, and Elektra.

Vs System 2PCG: Legacy also includes replacement main character cards for Thanos as the original cards in The Marvel Battles set were subsequently shown to distort play on the tournament scene.